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No particular dose adjustment proposed when tofacitinib coadministered with powerful CYP2C19 inhibitors; lessen tofacitinib dose if coadministered with both equally average CYP3A4 and powerful CYP2C19 inhibitors .fosphenytoin will minimize the extent or result of modafinil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep